Dr MB’s 5MTHF (Vitamin B9)

£30.00

Dr MB’s 5MTHF

Vitamin B9 is one of the 13 essential vitamins.

Folic acid is only one type of folate and it must be converted to tetrahydrafolate before it can be used in the body. This activity requires a methyl group to be added to the molecule before the body can utilize it. This process requires several cofactors to make the conversion, these include:

  1. a diet high in uncooked leafy greens
  2. a body with functioning enzymes
  3. available receptors in the body
  4. the ability of the body to transport the molecules, and
  5. vitamin cofactors of B2, B6 and B12 in an acidic environment to provide absorption.

When folate that is already methylated (methyltetrahydrafolate – MTHF), its ingested provides the body with a more readily available source and requires few cofactors for the body to be able to use this product.

Folate is responsible for many functions in the body including: DNA production and repair, methylation, conversion of amino acids to neurotransmitters, and the maturation of RBC, WBC and platelets. Folate-deficient women have lower oocyte (egg) quality, lower pregnancy rates, and impaired ovarian function. Folate helps to convert homocysteine to methathione. Women with lower homocysteine levels have better quality oocytes and higher degree of mature oocytes then women who did not receive the supplementation.

If there are low levels of folate in a mother’s diet it can result in birth defects, pregnancy loss, and miscarriage.

Folate conversion affects glutathione production in the body. Glutathione helps the body to detoxify environmental stresses (chemicals, food additives, bacteria, medications, etc). If the body has low (or limited amounts) of glutathione, the stressors cause increased damage to the cells especially the mitochondria. Mitochondria are important for producing energy in the body.

Many people are heterozygous or homozygous for the gene mutation that impairs folate conversion in the body. Meaning that in addition to having the cofactors and environment discussed above, the mechanism in the body that converts can only work at 30 – 50% of its optimal level to convert folic acid to useable methyl folate in the body. In these cases, patients should consume methyl folate (MTHF).

To determine the right amount of folate to take, consult your naturopathic doctor, who can determine other sources of folate in your diet as well as lifestyle and environmental influences that may require you to take higher or lower dose of methylfolate.

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Description

Methyl folate (5 MTHF, L-5-methyltetrahydrofolate)

Methyl folate, also known as 5 MTHF, is an active form of folic acid, a vital vitamin. Unlike regular folic acid, which needs conversion in the intestines and liver, some individuals cannot achieve this due to dysfunction. However, 5 MTHF guarantees absorption and overcomes the ineffectiveness of folic acid.

Moreover, 5 MTHF acts as a methyl donor, converting homocysteine to methionine, a process that reduces the risk of cardiovascular disease. Both methyl folate and methyl B12 have demonstrated this capability.

For individuals planning to conceive, both men and women, it is recommended to use methyl folate to enhance the cellular health of sperm and eggs. Additionally, during pregnancy, its usage is advised to decrease the chances of low birth weight and neural tube defects.

Notably, folate contributes to various essential functions, such as:

– Maternal tissue growth during pregnancy – Folate actively contributes to the growth of maternal tissues during pregnancy. Specifically, the bioactive form, 5 MTHF, plays a vital role. It supports DNA synthesis, cell division, and the rapid proliferation of maternal tissues. Inadequate folate intake can lead to complications and increased pregnancy risks. Thus, ensuring sufficient folate levels through diet and supplementation is crucial for optimal maternal tissue growth and a successful pregnancy outcome.

– Normal amino acid synthesis – Folate actively contributes to the growth of maternal tissues during pregnancy. Specifically, the bioactive form, 5 MTHF, plays a vital role. It supports DNA synthesis, cell division, and the rapid proliferation of maternal tissues. Inadequate folate intake can lead to complications and increased pregnancy risks. Thus, ensuring sufficient folate levels through diet and supplementation is crucial for optimal maternal tissue growth and a successful pregnancy outcome.

– Normal blood formation – Folate is vital for normal blood formation. It supports hematopoiesis, the production of new blood cells. As a coenzyme in DNA synthesis, folate is essential for red blood cell, white blood cell, and platelet production. Insufficient folate levels can lead to anemia and impaired oxygen transport, causing fatigue and weakness. Adequate folate is necessary to maintain healthy blood cell production. Including folate-rich foods like leafy greens, citrus fruits, and legumes in the diet is crucial. In some cases, folate supplementation may be needed, especially during pregnancy or for those at risk of deficiency. Folate’s role in normal blood formation ensures proper functioning of blood cells and overall well-being.

– Normal homocysteine metabolism – Folate is crucial for normal homocysteine metabolism, an amino acid produced during protein breakdown. Elevated homocysteine levels pose cardiovascular risks. Folate’s methylation process converts homocysteine into methionine, an essential amino acid with physiological importance. By supporting homocysteine metabolism, folate maintains optimal levels for cardiovascular health. Inadequate folate intake or impaired metabolism leads to high homocysteine levels. Thus, ensuring sufficient folate through diet or supplementation is vital to promote healthy metabolism and reduce cardiovascular disease risks.

– Normal psychological function – Normal psychological function is crucial for well-being. Folate contributes to it by supporting neurotransmitter synthesis and regulation. Adequate folate intake promotes mental health and cognitive abilities.

– Normal function of the immune system – Folate is crucial for maintaining a healthy immune system. It supports the production and maturation of immune cells, aids in DNA and RNA synthesis, and defends against pathogens. Inadequate folate can weaken the immune response, increasing vulnerability to infections. Sufficient folate intake through diet or supplementation is vital for a strong immune system and overall well-being.

– Reduction of tiredness and fatigue – Folate actively plays a crucial role in reducing tiredness and fatigue. It helps in the production of energy in the body by assisting in the metabolism of carbohydrates, proteins, and fats. Adequate folate levels support optimal energy production, which can help combat feelings of tiredness and fatigue. Ensuring sufficient folate intake through diet or supplementation is important for promoting energy levels and overall vitality.

– Process of cell division – Folate actively contributes to the process of cell division. It supports DNA synthesis and replication, ensuring accurate duplication of genetic material. Adequate folate levels promote proper growth, development, and tissue repair. Insufficient folate impairs cell division, leading to health issues. Thus, ensuring sufficient folate intake is crucial for optimal cell division and overall cellular health.

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