P5P actively participates in various essential processes within your body. It is involved in amino acid metabolism, heme biosynthesis, neurotransmitter biosynthesis, collagen formation, and glucocorticoid action.
Moreover, P5P plays a crucial role in maintaining the balance of sodium and potassium levels by regulating the electrical functioning of your nerves, heart, and musculoskeletal system.
Working independently or in conjunction with other enzymes, P5P aids in the synthesis and breakdown of amino acids, as well as in their conversion from one form to another.
Additionally, P5P assists in the release of stored energy from your liver and muscles, while promoting the production of antibodies and red blood cells.
Burning feet (diabetic neuropathy)
Experiencing a painful, burning sensation in the soles of your feet is known as burning feet. This condition arises from nerve damage in the foot, either directly from frostbite or other injuries, or indirectly from poorly managed diabetes, a stroke, rheumatoid arthritis, or gout. The pain tends to intensify during nighttime. P-5-P, also known as vitamin B6, has been proven to alleviate nerve pain associated with diabetic neuropathy, a prevalent cause of burning feet. In a study where P-5-P was combined with thiamin (another B vitamin), 88% of participants reported reduced pain within just 4 weeks, accompanied by nearly a 50% decrease in peripheral neuropathy symptoms.
Autism and Brain Function
The combination of magnesium and P-5-P proves highly beneficial for children with autism. When supplemented with these nutrients, improvements in social interactions, communication, and overall functioning have been observed. Interestingly, studies have shown that children with autism may not effectively process regular vitamin B6, making the active P5P form more advantageous as it does not necessitate conversion. Furthermore, P-5-P serves various other purposes in brain health, such as alleviating depression and aiding in the prevention of migraine headaches. Additionally, it contributes to reducing homocysteine levels, thereby playing a role in the prevention of Parkinson’s and Alzheimer’s diseases.
P5P and Cardiovascular Risk
As per John Ellis’ book “Vitamin B6 Therapy: Nature’s Versatile Healer,” P5P effectively reduces homocysteine levels in the body. Unlike homocysteine, which is not derived from the diet but rather from the amino acid methionine, P5P has the ability to diminish methionine levels, leading to decreased homocysteine production. This reduction is significant because elevated homocysteine poses a potential risk for cardiovascular disease. Moreover, P5P offers protection against coronary heart disease, hypertension, and cerebral vascular disease.
As per “Cecil Medicine: Expert Consult,” P5P deficiencies could potentially play a role in pancreatic and cervical cancers. Women diagnosed with cervical cancer often exhibit a vitamin B-6 deficiency. In relation to pancreatic cancer, a study published in the “Journal of the National Cancer Institute” indicated that 26 percent of the studied cases might have been preventable through prior P5P supplementation.