What Is Sulforaphane?
Sulforaphane (SFN) is a phytochemical compound that’s naturally found in some vegetables, specifically those in the Brassica (or cruciferous) plant family. This includes veggies like broccoli, cabbage, Brussel sprouts and cauliflower.
You can obtain sulforaphane from eating these vegetables, plus from supplements (such as those made from broccoli sprouts) that contain concentrated extract forms of SFN.
Technically, SFN is a type of aliphatic isothiocyanate. It’s thought to have high bioavailability compared to other phytonutrients, making it very useful for potentially helping prevent and treat diseases, especially cancer.
SFN is produced by the conversion of glucoraphanin through the enzyme called myrosinase.
Benefits of SFN
Is sulforaphane anti-inflammatory? Yes — it’s been shown to have anti-inflammatory and antioxidant-like effects and help fight oxidative stress.
Here’s more about how SFN can benefit various aspects of your health:
1. Helps Reduce Inflammation
A number of studies have found that sulforaphane can help reduce biomarkers of inflammation, including among both overweight and otherwise healthy adults. This suggests that SFN can help manage inflammation-related conditions, including arthritis, cardiovascular disease and others.
One way in which SFN suppresses inflammation and oxidative stress is by impacting NF-κB, a key regulator of inflammatory responses. It can also down-regulate proinflammatory enzymes, such as cyclooxygenase (COX-2) and NO synthase (iNOS), giving SFN cancer-fighting and anti-carcinogenic effects.
SFN also supports a strong immune system by enhancing natural killer cell activities and other markers of enhanced immune function. Therefore, it’s thought to have the ability help prevent both chronic and acute/infectious diseases.
2. Can Help Prevent Diabetes
SFN works as an indirect antioxidant in a way that reduces the risk for type 2 diabetes and its complications, such as neuropathy (nerve damage).
It can help prevent oxidative stress and lipid peroxidation, which are thought to be important factors in the pathogenesis of diabetes complications. It may also help reduce LDL “bad cholesterol” and generally support cardiovascular health.
3. May Help in Treatment of Some Cancers
Because SFN can kill cancer cells and suppress tumor growth in their early stages, it’s used in extract form to treat certain types of cancer, such as prostate cancer and pancreatic cancer.
Sulforaphane has been shown to induce apoptosis (death of cancer cells), suppress cancerous cell cycles so their progression is limited, inhibit angiogenesis (formation of new blood vessels that allow tumors to grow) and anti-inflammatory activities, and inhibit metastasis (spreading of cancer to other locations in the body).
4. Supports Liver Function and Detoxification
Why is sulforaphane good for the liver? Due to its ability to boost antioxidant effects in the body and support phase 2 detoxification enzymes, it can help prevent the liver becoming damaged and dysfunctional.
Some of the ways it supports detoxification and liver function include:
- Inhibiting detoxification enzymes that activate chemical carcinogens.
- Reducing the level of toxic intermediates with carcinogenic potential.
- Increasing activity of phase 2 detoxification enzymes. Sulforaphane is actually considered the most potent of the phase 2 inducing substances. According to the National Cancer Institute, this is “a process in which the liver uses one of two major enzyme pathways to change a toxic substance, such as an anticancer drug, into a less toxic substance that is easier for the body to excrete.”
- Limiting the effect of aflatoxin on liver cells.
- Providing significant protection against environmental and food-borne pollutants.
5. Increases Synthesis of Glutathione (a “Master Antioxidant”)
Sulforaphane itself is not an actual antioxidant, but instead it exerts antioxidant effects primarily by induing glutathione and other antioxidant compounds. Therefore, it’s considered an “indirect antioxidant.”
This means that SFN can decrease oxidative stress, which is a major contributor to many age-related diseases.
SFN supports glutathione in promoting detoxification and protecting us against toxicity and disease. It can also provides DNA protection against harmful mutations.
6. Defends Against Lung Damage
Sulforaphane limits pro-inflammatory effects and harmful effects of chemicals that can contribute to various lung diseases. It improves the body’s ability to remove toxins related to respiratory diseases, and it’s a potent inducer of HO-1 (haemoxygenase-1), which plays an important role in modulating the effects of oxidants in the lungs.
7. Supports Gastrointestinal Function
By blocking growth of the harmful bacteria known as Helicobacter pyloris, SFN can help decrease the risk for gastric tumor and ulcer formation. It may also possibly protect against stomach cancer.
Because it can promote healthy microflora in the colon, SFN also potentially offers protection against colorectal cancer.
8. Protects the Brain From Damage
SFN is thought to have a positive impact on dopaminergic neurons in the brain, which are associated with Parkinson’s disease. Research shows that SFN helps prevent dopaminergic cells in the brain from experiencing cytotoxicity and neuronal death, which can contribute to Parkinson’s.
It may also help defend against other neurodegenerative diseases, such as Alzheimer’s disease, in part by protecting mitochondria.